UNAIR scientist studies activation of congenital immunity in MB Leprosy patients with ENL

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Illustration by Feri Fenoria

UNAIR NEWS – Dr. M. Yulianto Listiawan, SpKK (K), FINSDV, FAADV., continues to present extraordinary research results. His researches also focus on leprosy.

According to him, leprosy is a chronic infection caused by Mycobacterium leprae which mainly affects the skin and peripheral nerves. Clinical complaints, he said, depend on the patient’s primary cellular immune system. Complications in leprosy, he continued, are type 1 reactions and type 2 reactions or erythema nodosum leprosum (ENL).

“ENL is an acute inflammation caused by immune complex deposits that affect multibacillary (MB) leprosy patients,” he said.

Furthermore, he said that the research conducted was a cross-sectional analytic observational study with a comparison group. In that case, he continued, the observation group was MB leprosy patients with ENL reaction, while the comparison group was MB leprosy patients without ENL.

“The sample consisted of MB leprosy patients who met the inclusion criteria, had anamnesis, physical examination and bacteriology,” he said.

In the end, he also said that the overall results of the study showed activation of innate immunity in MB leprosy patients with ENL. Therefore, he continued, it is important to improve the ENL therapy approach that is consistent with its adaptive and active immunity.

“Further prospective studies are needed with observations in MB leprosy patients with and without ENL using the same variables as this study,” he concluded.

Author: Nuri Hermawan

Editor: Khefti Al Mawalia

Details of this research available at:


M. Yulianto Listiawan (2019). Comparison of TLR2/1, NF-кB p105/50, NF-кB p65, and TNF- α expressions in the macrophages between multibacillary leprosy patients with and without erythema nodosum leprosum signifying innate immune system activity. Bali Med J, 8(1): 347-53.

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