UNAIR NEWS – Angiogenesis is a process of forming new blood vessels, which plays an important role in wound healing and reproduction. In addition, angiogenesis also plays a role in the growth and spread of cancer cells. Therefore, the blood supply is needed for tumors to grow in living tissue.
Inhibition of angiogenesis has also been considered beneficial for the prevention of the growth of neoplastic cysts and chronic inflammatory diseases.
Responding to this, Muhammad Thohawi Elziyad Purnama, Drh., M.Si., one of the lecturers at Faculty of Veterinary Medicine PSDKU UNAIR in Banyuwangi with his team examined a natural material that could be used sustainably in terms of inhibiting the angiogenesis process.
“Because angiogenesis plays a role in the development of several diseases, including tumor growth and spread of cancer cells, therefore, the discovery of antiangiogenic agents is very important,” said the lecturer who is often called Thohawi.
According to Thohawi, one of the natural ingredients that can be used as an antiangiogenic agent is a tin leaf (Ficus carica L.). Plants that are often referred to as Tin or Fig, and are still closely related to the banyan tree and it contains various materials that can inhibit the formation of new blood vessels or angiogenesis.
“The extract from Tin leaves is used in traditional Iranian medicine for the treatment of papillomatosis, a respiratory disease. “In addition, it has been reported that Tin leaf extract also has a different therapeutic effect compared to other cancer cell inhibiting agents,” he explained.
Thohawi added that the research he conducted with the team was aimed at proving the efficacy of Tin leaf extract as antiangiogenic or anti-angiogenesis in the inhibition of new blood vessels and expression of vascular endothelial growth factor (VEGF).
“After we carefully examined the team using embryonic chicken egg material, it can be concluded that the administration of Tin leaf water extract can inhibit the formation of new blood vessels and inhibit VEGF expression,” said Thohawi.
The study used 25 embryonic chicken eggs divided into 5 treatments, and each treatment applied 5 repetitions. And the extra tin leaves used are divided into several doses, which are 75, 90, and 110 mg.
“More precisely, the optimal dose of Tin leaf extract is 90 mg, because it has been able to inhibit the formation of new blood vessels by 65.51% and reduce VEGF expression by 45% in embryonic chicken eggs,” he added.
As a lecturer and researcher, Thohawi expects all researchers to utilize all-natural materials that are around us and make it as sustainable research.
“Not only looking for natural ingredients that are new, developing and optimizing ingredients that have been found, I think it is easier than having to find new materials,” he concluded. (*)
Penulis : Bastian Ragas
Editor: Nuri Hermawan
Sumber : Hamid I.S, Aksono E.B, Sukmanandi M, Purnama M.T.E. 2018. Antiangiogenesis activity test of tin leaf (Ficus carica L.) on the number of blood vessels and VEGF expression of chorioallantoic membrane of embryonated chicken eggs. European Journal of ONCOLOGY PHARMACY, 1:4.
