The effect of maintaining mice sperm quality exposed to dioxin

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Illustration by Bang-isman.com

One of the many pollutants in the Persistent Organic Pollutant (POPs) class can disturb the ecosystem. Many Persistent Organic Pollutants are prohibited because it has toxicity to the biotic ecosystem, including dioxin compounds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). dioxin compounds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) also reprotoxic properties, which means it can cause toxicity to the reproductive system, especially male reproduction. Dioxin exposure can cause a decrease in spermatozoa concentration.

Chebar grass contains active antioxidants and potential vitamins to neutralize TCDD toxicity. It is proven that the extract of Chebar grass in various doses can maintain viability, motility, and sperm concentration of exposed male mice. 2,3,7,8-tetrachlorodibenzo-p-dioxin. This study is an experimental laboratory study with five groups: negative control (K-), positive control (K +) with exposure to TCDD 0.7μg / Kg BW IP single dose. Giving Chebar grass extract orally for 53 days of treatment 1 (P1) at a dose of 0.045 mg / g BW, treatment 2 (P2) at a dose of 0.08 mg / g / BW, and Treatment 3 (P3) at a dose of 0.135 mg / g / BW. The spermatozoa motility, viability, and concentration data were analyzed using One Way Anova Test and Duncan’s Multiple Range Test.

The results showed that the administration of kebar grass extract at a dose of 0.135 mg / g / BW gave a significant difference between the control group and the treatment group (p <0.05). Exposure to TCDD in the positive control significantly reduced motility (13 ± 6.70%), viability (28 ± 19.35%), and spermatozoa concentration (0.87 ± 0.64 cells / mm3) compared to the normal control group. . The administration of Chebar grass extract at a dose of 0.135 mg / g / BW in treatment group 3 can maintain motility (74 ± 5.47%), viability (76 ± 2.72%), and spermatozoa concentration (2.50 ± 0.69 cells / mm3). This study concludes that the extract of Kebar grass can effectively maintain the quality of spermatozoa mice from damage due to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Author: Prof. Dr. Widjiati., MSi., Drh
Link: https://pharmascope.org/ijrps/article/view/2817/6059

Muhammad Faiz Labib, Widjiati, Tatik Hernawati, Epy Muhammad Luqman, Rochmah Kurnijasanti, Tri Wahyu Suprayogi. 2020. Kebar grass (Biophytum petersianum K.) The effect of maintaining mice (Mus musculus) sperm quality exposed to dioxin.

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