There is a relationship between the sense of the oral cavity and a state of obesity suffered by an individual. At this time, many individuals who like to work the easy way, so that triggers the occurrence of degenerative diseases related to changes in lifestyle (lifestyle), which tends towards a sedentary lifestyle, aka they want to eat anything but do not want to do physical activity.
The sense of taste in humans consists of two major groups. Namely the primary sense of taste (including sweet, salty, bitter, umami or savory, and sour), while the additional sense of taste of race (includes the sense of taste of spicy, water, fat, calcium and metal). The sense of taste associated with obesity is salty and sweet. Someone with obesity will experience interference with the sense of taste sweet. It was causing the consumption of sugar, which will be more excessive.
Obese individuals are prone to hypertension caused by salty taste receptors (ENaC) and water receptors, namely: Aquaporin2 by the workings of salty taste receptors will absorb a lot of water, which will increase the workload of the heart and cause heart pressure longer more increasing.
Obesity is associated with high levels of bad fat (Low Density Lipoprotein) or LDL, which causes plaque buildup. Both the main blood vessels of the heart and peripheral blood vessels. This will trigger the formation of Reactive Oxygen Species (ROS), which are free radicals. The body does have anti-oxidants that can be used to fight free radicals. Still, if there is an increase in the number of free radicals that are higher than anti-oxidants, then there is a state of instability that harms cell life, especially heart muscle cells. The plaque will accumulate and continue to accumulate so that at any time can inhibit the flow of blood pumped out by the heart.
This link lies in the receptor cluster of differentiation 36 (CD 36), which turns out to be present on the human tongue, which is associated with the sense of fat taste. Plaque buildup in the walls of blood vessels uncontrollably can also cause an inflammatory reaction because the plaque is recognized as a foreign body (immunogen). After immunogens being recognized by the body’s immune system, there will be an inflammatory reaction that clogs the blood vessels and triggers atherosclerosis. The blockage can also be associated with the risk of stroke that can arise due to the rupture of peripheral blood vessels due to a reduction in blood vessel diameter because LDL cholesterol plaques cover it.
Based on the statement about the relationship between obesity and the sense of taste, obesity sufferers should always increase physical activity, given that technological advancements can cause people to be lazy to do things that people used to do back then. Very ironic with the increase and progress of the era, which is very fast, but almost all of its inhabitants experience degenerative diseases and silent killers. It can be prevented by doing physical activity every day regularly to help the process of cell metabolism in destroying plaque and increasing levels of good cholesterol (High-Density Lipoprotein) or HDL.
Besides, to prevent the possibility of the emergence of diabetes in obese individuals, it is expected that individuals reduce the intake of processed foods containing lots of sugar/glucose and return to a healthy life, and carry out physical activities and are not spoiled by facilities in modern times. The advice given is to reduce the consumption of sugar and salty and umami, which is one of the preventive ways to prevent the onset of death caused by cell damage and end in death due to obesity.
Author: Jenny Sunariani
Link:
Jenny Sunariani. 2020. Cluster of differentiation 36 (CD 36), ENac, and AQP 2 effects on heart. IOP Conference Series: Earth and Environmental Science, Volume 441, Issue 1.
