UNAIR NEWS – The Central Statistics Agency said that Indonesia has the biodiversity of potential medicinal plants to be developed as medicines. Today, the use of raw materials for traditional medicine by the community reaches approximately 1000 species, of which 74% are wild plants that live in the forest.
World Health Organization (WHO) says as much as 80% of people in developing countries implement traditional medicine. Traditional medicine is now used as an alternative medicine to modern medicine. Traditional medicine is more trusted because it is judged to be safer and it is suspected that there is a complementary effect in traditional medicine which is considered beneficial. People re-use medicinal plants because traditional medicines have lighter side effects than synthetic drugs.
Dr. Hendrik Setia Budi, drg., M. Kes, Lecturer at Faculty of Dental Medicine UNAIR said that ambonese banana (Musa paradisiaca var.sapientum) is a plant that is found in Indonesia, especially in tropical areas. In plants containing lectins with high concentrations can be used to heal wounds through the process of coagulation or the formation of blood clots.
“The results of research on the administration of galectin-3 which is a lectin group showed that there was an increase in Vascular Endothelial Growth Factor (VEGF) and Basic Fibroblast Growth Factor (b-FGF) on the response to angiogenesis,” he said.
Whereas, previous studies showed that topical administration of ambon banana stem sap with doses of 30 and 60 mg in the socket area showed an increase in fibroblasts and osteoblasts with the release of PDGF-BB, BMP-4 and BMP-7 cell signals in the healing process of rat tooth extraction wounds. “
“To clarify this, an experimental laboratory study was carried out using the post-test only control group design. The unit of analysis is the socket of the lower right incisors of rats that have been extracted, “said Dr. Hendrik Setia Budi, drg., M. Kes,
Examination data of MMP-2 collagen damaging cell signal (matrix metalloproteinase 2) and MMP-9 (matrix 9 metalloproteinase) on socket healing days 7 and 14 by immunohistochemical methods, showed brown cells. MMP is an enzyme that plays an important role in tissue renovation associated with various physiological or pathological processes such as morphogenesis, angiogenesis, tissue repair, cirrhosis, arthritis, and metastasis.
The test results showed a correlation of 0.963, which means there is a significant relationship between MMP-2 collagen damage cells and MMP-9 to collagen density in the healing process of tooth extraction wounds that were given ambon banana stem gel.
Author: Tunjung Senja Widuri
Editor: Khefti Al Mawalia
Hendrik Setia Budi, Eha Renwi Astuti (2019). The MMP-2, MMP-9 Expression and Collagen Density of the Ambonese Banana Stem Sap Administration on Wound Healing. J Int Dent Med Res 2019; 12(2): 492-497.