Experts reveal stem cells as skin rejuvenation therapy

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Illustration by Feri Fenoria

UNAIR NEWS – A decrease in the capacity of skin tissue growth, decreased viability, impaired keratinocytes, reduced collagen production, and decreased elastic fibers make skin aging due to exposure to sunlight from ultraviolet radiation. Dr. Ni Putu Sussari Widianingsih, Sp.KK, FINSDV, FAADV revealed that aging is characterized by the appearance of wrinkles, thinning skin, rough skin, skin discoloration, telangiectasis (widening of small blood vessels), and sagging skin.

“The skin aging occurs because of increasing age caused by internal factors such as genetic, photoaging such as ultraviolet radiation,” she said.

Regarding this matter, Ni Putu Sussari Widianingsih and her team researched the development of therapies that are suitable for rejuvenating the skin. The possible treatment is by using stem cells or stem cells. According to him, stem cells contain cytokines, growth factors, and other bioactive proteins that help the healing process.

“Stem cells can be taken from amnion, chorion, amniotic fluid and Wharton jelly which can be easily extracted, safe, and without immunogenic and tumorigenic effects,” she said.

The existence of growth factors is a discovery in skin rejuvenation therapy. Growth factors are hydrophilic molecules (linked to water) that are more than 20 kDA in size, but it is known that hydrophilic molecules (linked to water) that are more than 500 DA will be challenging to penetrate the skin.

“A method is needed to deliver growth factors into the skin. Potential methods that are currently available: transepidermal drug delivery (TED), laser-assisted transdermal delivery (TDD) that uses fractionated lasers to reduce side effects, “she said.

The use of fractionated lasers is aimed at making holes in the stratum corneum (the outer layer of the skin). It can damage the epidermis, causing side effects such as redness, swelling, blisters, sometimes causing infections, and changes in skin pigmentation that is reversible or permanent. Fractional CO2 laser therapy could facilitate the transfer of topical drugs into the skin. However, other treatments have been found because they have smaller side effects, namely erbium-doped yttrium aluminum garnet (Er-YAG) laser fractional ablative therapy.

“These therapies can help to facilitate the transfer of drugs into the skin including AMSC,” she said.

The results of a study involving nine women aged 41-57 years revealed that Yag laser fractional erbium therapy combined with the administration of AMSC metabolite products was beneficial and safe. Skin rejuvenation therapy options are suitable for patients in Asia.

“This therapy can deliver AMSC metabolite products into the skin and facilitate their absorption so they can work better to overcome skin problems,” she concluded.

Author: Khefti Al Mawalia

Editor: Nuri Hermawan

Full article available at:

Ni Putu Susari Widianingsih, Trisniartami Setyaningrum, Cita Rosita S. Prakoeswa. 2019. The efficacy and safety of fractional erbium yag laser combined with topical amniotic membrane stem cell (AMSC) metabolite product for facial rejuvenation: A controlled, split-face study.

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Media komunikasi dan informasi seputar kampus Universitas Airlangga (Unair).

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