UNAIR NEWS – There are 8 – 12 percent of couples suffering from infertility worldwide and 40-50% is caused by male infertility. There are many factors causing cell damages. One of them is free radicals attacking cell metabolites directly and causing a decrease in energy levels in the movement and function of sperm cells.
Seeing this problem, a lecturer of Faculty of Veterinary Medicine Dr. Budi Utomo M.Si, drh invented herbal medicine to go back to nature. Herbal medicine offers several medical benefits because of its active contents.
“Phaleria macrocarpa or God’s crown is one of the herbs that are reported to contain flavonoids, phenolic, saponins, alkaloids,” he explained.
According to him, the extract of God’s crown fruit flesh is able to improve male fertility. He had studied it using the white rat sperm experiment. The God’s crown, he continued, was then extracted as therapeutic material with three doses of the extract for three treatments, 7.5 mg / kg for P1, 15 mg / kg for P2, 30 mg / kg for P3, and the control group (P0) were given 0.5% CMC-Na for 21 days.
“This study showed that the administration of God’s crown meat extract results in improved sperm motility and viability due to antioxidant effects,” he said.
Antioxidants such as flavonoids, he continued, serve to provide protection for the plasma membrane and reduce the amount of excessive free radicals. Free radicals are neutralized by antioxidants by increasing the lack of electrons from the chain reaction and blocking the chain reaction from forming free radicals. Thus, oxidative stress will not occur in the body or cells.
“However, when the dose of antioxidants and prooxidants is out of balance, the body will form prooxidants to balance the path. It resulted in the smooth integrity of the sperm plasma membrane, “he explained.
In this study, Dr. Budi hoped that the extract of God’s crown fruit is consumed at the right dose because if it is not on the right dose, it will have a cytotoxic effect.
Author: Khefti Al Mawalia
Editor: Nuri Hermawan
Amaq Fadholly, Arif Nur Muhammad Ansori, Annise Proboningrat, Muhammad Khaliim Jati Kusala, Naimah Putri, Soeharsono, Budi Utomo. Phaleria macrocarpa (Scheff.) Boerl. Pulp Extract Increase the Sperm Characteristics in Rattus norvegicus. Indian Vet J. October 2019, 96(10): 32-35.