Pyrophosphate Toothpaste and Papain Prevent the Scaling of Teeth

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Preventing calculus formation is very difficult to overcome. Calculus formation is the result of deposition or crystallization process from material in saliva, namely calcium and phosphorus. Calculus formation is also influenced by pH level or low amount of hydrogen ions in the oral cavity, or arguably the alkaline pH conditions and these basic conditions are caused by an easy crystallization process.

Patients who use fixed orthodontic devices are more susceptible to calculus formation than patients without orthodontic treatment. Pyrophosphate toothpaste and papain can be used to reduce dental plaque and accumulated calculus. The purpose of this study is analyzing the differences in calcium levels and phosphate levels in saliva, as well as the pH of saliva in patients after being treated with toothpaste containing pyrophosphate and papain. The material and method of this research are true experimental research with a pre-test and post-test control group design with random sampling. The sample size is (n = 20).

Samples were male or female patients aged 17-22 years using fixed orthodontic appliances. The sample was divided into two groups: the control group that was given placebo toothpaste and the treatment group with toothpaste containing pyrophosphate and papain by a blind method. Patients are instructed to brush their teeth twice a day every day. 3 ml of unstimulated saliva were collected on days 1, 3, and 5. Atomic absorbance spectrophotometer (SAA) was used to measure calcium and phosphate levels in saliva. The measurement of saliva pH uses a pH meter.

The results of this study indicate the lowest average level of calcium. Calcium levels in the treatment group between groups (p 0.05). The treatment group showed the lowest phosphate on day 5. Phosphate levels in the treatment group between groups (p

Author: Dr. I Gusti Aju Wahju Ardani, drg., M. Kes. Sport. (K).

Detail information from this research can be seen in our writing at

I Gusti Aju Wahju Ardani, Monika Nilam, Hana Arya Puspita, Ida Bagus Narmada. 2019. Effectiveness of Toothpaste containing Pyrophosphate and Papain to Inhibit Calculus Formation in patient using Fixed Orthodontic Appliance. Research J. Pharm. and Tech. 12(8). DOI: 10.5958/0974-360X.2019.00650.4

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