Instead of Damaging Kidneys, Metformin Gives Protection

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metformin expert
Head of the Indonesian Endocrinology Association (PERKENI) Prof. Dr. dr. Askandar Tjokroprawiro, SpPD, K-EMD, FINASIM explains about the use of Metformin drugs for lowering the blood sugar. (Photo: Sefya Hayu Istighfaricha)

UNAIR NEWS – In order to control the blood sugar, a diabetic should take medicine regularly for lowering blood sugar such as Metformin. Unfortunately, this routine often felt tedious. Some even assume that taking diabetes drugs too often can damage the kidneys. Is it true?

Metformin has long been used as a drug therapy for people with diabetes. Even the Guide Line of the American Diabetes Association (ADA) established Metformin as first-line therapy.

Responding to public concern on taking diabetes drug routinely, Head of Indonesian Endocrinology Association (PERKENI) Prof. Dr. dr. Askandar Tjokroprawiro, SpPD, K-EMD, FINASIM confirmed that diabetes drugs and hypertension drugs will not adversely affect the kidneys.

Routine consumption of diabetes drugs and hypertension would be a protection for the kidneys and other organs.

“If these drugs are not consumed, consequently blood sugar and blood pressure is uncontrolled. This is what will actually damage the kidney, “he said after attending The Quadriple Joint Symposium 2018 at JW Marriot Hotel 10-11 February 2018.

Biomolecularly, Metformin has 100 benefits. In addition to being used as a diabetes drug, Metformin also gives a protective effect on the metabolic system, heart, prevents tumor cell growth (MCRC), and prevents the effects of nicotine on cancer risk.

Metformin is also well consumed by fatty food enthusiasts. Because, the effect of Metformin is known to inhibit the occurrence of narrowing of blood vessels.

The protective effect obtained from Metformin has been widely proven through a number of research abroad. Paul et al. Journal of Diabetes 2016 in the UK studied 82,205 DM patients to identify the correlation of smoking with the use of Metformin.

From the research, it was found that diabetics who smoked and took Metformin had a risk of coronary heart disease and stroke by 24 percent lower compared with people with diabetes who did not take the drug. In fact, the risk of death was only 48 percent lower than those with diabetics who did not take Metformin.

“If Metformin is consumed by people with heart attacks, then the infarction will not be easily expanded,” he explained.

Many studies have shown more benefits of Metformin drugs. Taking Metformin in the long term is known to reduce tumor lump in the breast and colon. In addition, if Metformin is consumed by patients with lung cancer, then life expectancy is estimated to reach 23 percent.

Some types of drugs when consumed more than the recommended dose can be give risk of damaging the kidneys, such as painkillers and rheumatic drugs.

“As long as it is consumed with the right dose, then these drugs are safe,” said Professor of Internal Medicine of FK UNAIR.

Although it provides protection, the use of Metformin should still be accompanied by a doctor’s recommendation. In order to use Metformin better, then the doctor needs to ensure in advance the condition of the patient’s kidney. Because the use of Metformin should be balanced with good kidney conditions, and consumed in the appropriate dosage.

“Metformin consumption cannot be arbitrary. The dose is 500-200 ml / gram per day with a good condition of the kidneys should be good, otherwise, Metformin will give a cumulative effect of sedimentation in the kidneys, “he explained.

With all the goodness of Metformin, Prof. Askandar emphasized the importance of preventive efforts.

“The most important thing is to improve lifestyle, maintain diet, routine physical activity, and avoid smoking,” he said.

Author: Sefya Hayu Istighfaricha

Editor: Binti Q. Masruroh

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