UNAIR NEWS – “The oral cavity is a very unique ecosystem”. It was the statement of Faculty of Dental Medicine’s (FKG) professor of Universitas Airlangga, Prof. Dr. Tuti Kusumaningsih, drg., M.Kes., in the professorship inauguration held in the Hall of Garuda Mukti Management Office, Saturday, September 16.
In her oration, the 17th active professor of FKG UNAIR presented an oration titled “Oral Antimicrobial Peptides (AMPs) as Models to Design Effective Antibiotics”. According to Tuti, AMPs or better known as natural antibiotics in the saliva is an important element to maintain a balance between healthy and pain in the oral cavity.
Furthermore, Prof. Tuti also explained that in the oral cavity there are many microorganisms, either beneficial or detrimental. Disadvantageous microorganisms will usually cause diseases such as dental caries, periodontitis and peri-implantitis.
“They are considered as chronic infectious diseases,” explained Tuti.
Furthermore, Prof. Tuti later also explained that some microorganisms such as Streptococcus mutans, Lactobacillus acidophilus, and Actinomyces viscosus, can cause colonization and form bacteria that cause biofilm plaque on tooth surfaces and shown to be a major contributor to the occurrence of infectious diseases.
“For that purpose the efforts of antimicrobial preparations such as conventional antibiotics can effectively inhibit bacterial growth and biofilm formation,” she added.
Prof. Tuti also pointed out that during the last twenty years some types of antibiotics have been developed for clinical needs, but that is not enough to overcome the rate of bacterial resistance.
“Therefore, we need to find alternatives as safe antibiotics which do not cause adverse side effects,” said Prof. Tuti.
One of the best options for Prof. Tuti is to use either naturally occurring antimicrobial peptides or AMPs as well as enzymatic hydraulic results. According to Prof. Tuti, AMPs in both natural and synthetic form are considered as effective antibacterial agents with wide application perspective.
“Because it can be characterized by a broad spectrum antibacterial effect with high antibacterial efficacy at low concentrations,” she explained.
At the end of the oration, Prof. Tuti stated that AMPs are currently recognized as biomolecules that can be found everywhere. In addition, AMPs can also be synthesized from the simplest organisms such as bacteria to more complex organisms such as humans.
“In the future, AMPs are expected to be models for designing effective antibiotics to fight infections that occur in the oral cavity,” said Tuti.
Author: Nuri Hermawan
Editor: Defrina Sukma S