Researching Stem Cell for Jaw Disorder, Ni Putu Mira Graduated Best from S-3 FK UNAIR

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Dr. Ni Putu Mira Sumarta (Photo: Special)

UNAIR NEWS – Stem cell treatment has been greatly developed. One of the researches has been developed by Dr. Ni Putu Mira Sumarta, drg., Sp.BM, for her dissertation. To explore the potentials of stem cell treatment for Temporomandibular Disorder (TMD), Mira used umbilical cord tissue. Her excellent dissertation support her for being the best graduate for doctoral program in Faculty of Medicine (FK) Universitas Airlangga.

TMD or jaw joint disorder is a problem often found in the society. A researched showed from 20 to 30 percents or adult population have experienced TMD. One of the causes is cartilage defect on jaw joint. It can cause pain and chronic inflammation. Various method developed have not given long term excellent solutions. Mira hoped that stem cell treatment can give hopes for jaw joint cartilage regeneration.

Specifically, the cause of TMD as of now has not been known. Based on some cases, TMD was caused by a lot of factors, age, genetics, sex, occlusion, hyperlaxity, parafunctional habit, acute trama, bruxism, orthodontic treatment, trauma, infection, immunologic defect, metabolic, neoplasia, congenital or developmental.

“References showed that 30 to 50 percents of the current population experienced TMD, especially people in the age group of 20-40,” said Mira.

TMD is disorders of jaw joint and chewing muscles. TMD is divided into muscular and cartilaginous, with some symptoms such as pain, jaw functional problem, deviation and deflection, joint moving range limitation, clicking joint, lockjaw, headache, tinnitus, also visual changes.

The woman born in Gianyar, on March 29, 1978 focuses on mandibula cartilage defect which was caused by trauma with Human Umbilical Cord Stem Cell (HUCMSC) and the use of Platelet Rich Fibrin scaffold. Both were achieved from the vene autologous blood centrifugation. This implant was done to a mouse mandibula cartilage defect and there was regeneration happening.

IN her dissertation, Mira used stem cell cultivated from umbilical cord tissue called HUCMSC. Compared to the one from bon marrow, according to Mira, HUCMSC has shown osteogenic, chondrogenic and adipogenic differentiation. Even some researches have shown that HUCMSC chondrogenic differentiation potentials were better than from the bone marrow.

“The regeneration happens in temporomandibula cartilage with umbilical cord stem cell was better compared to MSC from the bone marrow,” she said. (*)

Author: Sefya Hayu Istighfaricha
Editor: Defrina Sukma S.

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