Cartilage Pad for Invertebral Disc Degeneration Patient Being Developed

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PKMPE team lead by Cutyta conducting hydrogel synthesis in UNAIR laboratory (Photo: Team Documentary)

UNAIR NEWS – Chronic Low Back Pain (CLBP) is one of health problems often found in the society. About 60-80% of the world’s population has experienced this low back pain. The causes were various. One of them is invertebral disc degeneration, which is the cartilage pad in the spine which functions as the buffer of body weight and body shock absorber.

Patients suffer from pain, numbness and weak body parts due to pressed nerves. There are many treatments of this low back pain such as conservative treatment and surgery. But they can cause complication and infection.

Based on the case, then five students of Biomedical Engineering, Faculty of Science and Technology (FST) Universitas Airlangga (UNAIR), Cityta Putri Kwarta (2012), Miftakhul Jannah (2012), Dina Kartika Putri (2012), Evlyn Anggraini Santoso (2013), and Wilda Kholida Annaqiyah (2013), succeded in creating injectable hydrogel based on polymer for invertebral disc degeneration.

Under the supervision of Dr. Prihartini Widiyanti, drg.,M.Kes., they submit their innovative finding in a Students Creativity Program on Exact Science Research (PKM-PE) entitled “Hyaluronic Acid (HA) – Polyethylene Glycol (PEG) Composition as Injectable Hydrogel for Invertebral Disc Degeneration Patients’ Therapy”. The proposal was received funding from General Directorate of Higher Education (Dirjen Dikti) of Ministry of Research and Technology in PKM-PE 2016.

Hasil Uji In Vitro Injection Model Hidrogel ke Agarose. (Foto: Dok Tim)
In Vitro Injection test results of Hydrogel model to Agarose (Photo: Team Documentary)

Cityta Putri Kwarta, the head of the team explained that in the development her team used natural polymer, Hyaluronic Acid and plastic polymer Polyethylene Glycol also added Horse Radish Peroxide enzyme as the main material of the hydrogel. These three materials were chosen because they are bio-compatible, bio-degradable, and non-toxic.

To fulfill the characteristic, hydrogel has undergone some tests, swelling test to see the swelling ability, degradation test  to see how long the sample survive in the body, cytoxicity test to measure the sample material toxicity, in vitro injection model test to see the hydrogel work process and Fourier Transform Infra Red (FTIR) test to describe chemical reaction in the material.

“So this injectable hydrogel has passed the tests and met the requirements to be cartilage pad hydrogel. Hopefully this research can be a reference for the next research on injectable hydrogel in the future,” she said. (*)

Editor : Bambang Bes

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